 | Bill Nighy
Billy Mack |
 | Gregor Fisher
Joe |
 | Rory MacGregor
Engineer |
 | Colin Firth
Jamie |
 | Sienna Guillory
Jamie's Girlfriend |
 | Liam Neeson
Daniel |
 | Emma Thompson
Karen |
 | Lulu Popplewell
Daisy, her Daughter |
 | Kris Marshall
Colin Frissell |
 | Heike Makatsch
Mia |
 | Martin Freeman
John |
 | Joanna Page
Just Judy |
 | Chiwetel Ejiofor
Peter |
 | Andrew Lincoln
Mark |
 | Keira Knightley
Juliet |
 | Hugh Grant
The PrimeMinister |
 | Nina Sosanya
Annie |
 | Frank Moorey
Terrence, who's in charge |
| Jill Freud
Pat the housekeeper |
 | Martine McCutcheon
Natalie |
 | Tim Hatwell
Vicar |
 | Laura Linney
Sarah |
 | Lyndon David Hall
The Wedding Singer |
| Jont Wittingtom
Guitarist |
 | Dan Fredenburgh
Jamie's bad brother |
 | Julia Davis
Nancy the Caterer |
 | Abdul Salis
Tony |
 | Alan Barnes
Movie Director |
 | Shaughan Seymour
Movie Cameraman |
| Helen Murton
Funeral Priest |
 | Edward Hardwicke
Sam's grandfather |
 | Caroline John
Sam's Grandmother |
| Gemma Aston
Family Mourner |
 | Thomas Brodie-Sangster
Sam |
| MAtt Harvey
Family Mourner |
 | Adrian Preater
Family Mourner |
| Joanna Thaw
Family Mourner |
 | Junior Simpson
Wedding DJ |
 | Alan Rickman
Harry |
 | Rodrigo Santoro
Karl |
 | Brian Bovell
Radio Watford DJ |
| Sarah McDougall
Receptionist |
 | Marcus Brigstocke
Mikey, DJ interviewer |
 | Richard Hawley
Alex, Deputy Prime Minister |
| Wyllie Longmore
Jeremy |
 | Gillian Barge
Cabinet Member |
| Richard Wills-Cotton
Cabinet Member |
| Kate Bowes Renna
Cabinet Member |
| Kate Glover
Cabinet Member |
| Nicola McRoy
Cabinet Member |
 | Declan Donnelly
Dec |
 | Anthony McPartlin
Ant
(as Ant McPartlin) |
| Elizabeth Margoni
Eleonore |
 | Elisabeth Margoni
Eleonore (as Elizabeth Margoni) |
 | Lucia Moniz
Aurelia |
 | Billy Bob Thornton
US President |
 | Peter Marinker
US Expert |
| Kier Charles
Press Conference Reporter |
| Doraly Rosen
Press Conference Reporter |
 | Meg Wynn Owen
PM's Secretary |
| Carol Carey
Natalie's replacement |
 | Jo Whiley
Radio DJ |
 | Sarah Atkinson
Billy's Video Vixen |
| CLaire Bennett
Billy's Video Vixen |
| Sarah Holland
Billy's Video Vixen |
| Vicki Murdoch
Billy's Video Vixen |
 | Meredith Ostrom
Billy's Video Vixen |
| Katherine Poulton
Billy's Video Vixen |
| Tuuli
Billy's Video Vixen |
 | Michael Parkinson
Parky |
 | Michael Fitzgerald
Michael, Sarah's brother |
| Ciaran O'Driscoll
Hospital patient |
 | Rowan Atkinson
Rufus, jewellery salesman |
| William Wadham
Bernie, Karen's son |
| Catia Duarte
Language student |
| Igor Urdenko
Language student |
| Nat Udom
Language student |
| Ines Boughanmi
Language student |
| Yuk Sim Yau
Language student |
 | John Sharian
Wisconsin taxi driver |
| Glenn Conroy
Barman |
 | Ivana Milicevic
Stacey, American Dreamgirl |
 | January Jones
Jeannie, American Angel |
 | Elisha Cuthbert
Carol-Anne, American Goddess |
| Web Butters
Radio 1 chart show DJ |
 | Laura Rees
Record company executive |
| Emma Buckley
Jamie's sister |
 | Sheila Allen
Jamie's mum |
| Terry Reece
PM's chaffeur, Terry |
| Colin Coull
PM's bodyguard, Gavin |
 | Margery Mason
Harris Street old lady |
 | Katharine Bailey
Harris Street little girl |
| Tiffany Boysell
Her friends |
| Georgia Flint
Her friends |
 | Joanna Bacon
Natalie's mum |
 | Bill Moody
Natalie's dad |
 | Billy Campbell
Natalie's octopus brother, Keith |
| Paul Slack
John's brother |
 | Adam Godley
Mr. Trench |
| Rebecca Frayn
Joanna, Daniel's dead wife |
 | Olivia Olson
Joanna Anderson |
| Ruby Turner
Mrs. Jean Anderson |
| Amanda Garwood
Backing-singer teacher |
 | Arturo Venegas
Mr. Anderson |
 | Claudia Schiffer
Carol |
| Patrick Delaney
Tommy, Carol's Son |
 | Helder Costa
Mr Barros |
 | Carla Vasconcelos
Sophia Barros |
| Stewart Howson
Airport Gate Man |
| Jamie Edgell
Airport Guard |
| Dave Fisher
Airport Guard |
 | Paul Heasman
Airport Guard |
| Tony Lucken
Airport Guard |
 | Raul Atalaia
Restaurant proprietor |
| Nancy Sorrell
Greta |
 | Shannon Elizabeth
Harriet, the sexy one |
 | Denise Richards
Carla, the real friendly one |
 | Richard Curtis
Trombone Player |